CasNo： 1108745-30-7
The invention discloses a method for pre...
This disclosure relates to bivalent comp...
Provided herein are compounds, pharmaceu...
The invention provides a preparation met...
5-(3,5-difluorobenzyl)-2-fluorobenzonitrile
5-(3,5-difluoro-benzyl)-1H-indazol-3-ylamine
| Conditions | Yield |
|---|---|
|
With hydrazine; In butan-1-ol; at 120 ℃;
|
92% |
|
With hydrazine hydrate; In butan-1-ol; at 120 ℃;
|
92% |
|
With hydrazine hydrate; In butan-1-ol; at 120 ℃;
|
89% |
|
With hydrazine hydrate; In butan-1-ol; at 120 ℃;
|
89% |
|
With hydrazine hydrate; In butan-1-ol; at 120 ℃;
|
89% |
|
With hydrazine hydrate; In butan-1-ol; at 120 ℃;
|
60.1% |
|
With hydrazine hydrate; In butan-1-ol; Reflux;
|
C8H8BrN3
3,5-difluorophenylboronic acid
5-(3,5-difluoro-benzyl)-1H-indazol-3-ylamine
| Conditions | Yield |
|---|---|
|
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); In toluene; at 110 ℃; for 3h; Inert atmosphere;
|
78.5% |
5-(3,5-difluorobenzyl)-2-fluorobenzonitrile
C8H8BrN3
3,5-difluorophenylboronic acid
2-fluoro-5-formylbenzonitrile
N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-2,2,2-trifluoro-acetamide
2,6-dichloro-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]pyridine-3-carboxamide
methyl 4-{[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]carbamoyl}-3-nitrobenzoate
N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-2-nitro-4-(piperidin-1-ylmethyl)benzamide
